NFL power rankings Week 5: No. 1 spot changes hands for third consecutive week

1. San Francisco 49ers (4): Would have put them in the top spot sooner if not for concern regarding their latest rash of injuries, FB Kyle Juszczyk the latest star to go down . However, the Niners are certainly safeguarding QB Brock Purdy, becoming the first team since Peyton Manning's 2005 Colts to permit zero sacks through four games. Beat Seattle on Sunday, and San Francisco will have already taken down three of last season's final four teams. Unbeaten through four games for the third time under Kyle Shanahan, now the longest-tenured coach in franchise history , the 49ers leveraged those other two hot starts into Super Bowl berths.

2. Kansas City Chiefs (2): Will the AFC's final undefeated team have anyone left to play wide receiver on the other side of their Week 5 bye after losing Rashee Rice and Tyquan Thornton in Vegas on Sunday? Maybe an old friend ?

3. Seattle Seahawks (3): Even with RB Jadarian Price joining Zach Charbonnet on the shelf, they're doing a nice job with a patchwork running game that's incorporating KR/WR Rashid Shaheed and, perhaps, veteran Joe Mixon eventually .