Golden Nuggets: Let Brandin Cook(s)

Can the 49ers handle a ferocious pass rush? It's great that the offensive line hasn't given up a sack. They haven't faced a defensive line this good yet. Seattle next week will be even better. Connor Colby and the interior o-line have exceeded my expectations so far, but this isn't Miami or Arizona.

Can the 49ers keep exploiting linebackers in coverage without their best wide receivers? Mike Evans might not play. All due respect to Brandin Cooks, but they need big games out of their non-WR skill players like George Kittle, Christian McCaffrey, and even a little Kyle Jusczyzk. That's always been the case but especially so against the "elite DB/vulnerable LB" combination that Denver has going.

Can the 49ers establish the run? Kansas City provided the blueprint in Week 1 when they forced the Broncos to miss 26 tackles.