NFL Injury Report, Week 4: Latest news, updates on Justin Jefferson, De'Von Achane more for fantasy football

Mayfield : Just when we thought we were clear of any new QB injuries … Mayfield left Sunday's loss to the Vikings with a dislocated right thumb . Head coach Todd Bowles told reporters on Monday that Mayfield will miss three weeks . That would put the QB in line to return in Week 7 vs. the Panthers. Jalon Daniels came in late in relief and he will get the first crack to replace Mayfield. Tampa Bay could also explore outside options as well if Mayfield is out long-term. Either way, this is a big downgrade for what was already a struggling Bucs passing game. It'll be difficult to trust players like Emeka Egbuka , Chris Godwin Jr. and Bucky Irving in fantasy.

Daniels : The Commanders say Daniels will be back at practice this week. Whether or not he'll be ready for Week 4 against the Colts is still to be seen. It would be surprising to see Daniels back so soon, but we'll see how his practice reports look this week. In any case, Marcus Mariota was solid in the Week 3 upset win over the Seahawks.

Achane : Miami lost its top running back early in the loss to the Chiefs on Sunday. And the worst was reported by ESPN Monday morning with Achane suffering a torn ACL , ending his 2026 season. Miami was already trending toward being one of the bottom-dwellers of the NFL and fantasy world this season. Losing Achane is the worst-possible scenario. With Achane sidelined, you can't really replace the type of player he is and that type of early-round draft capital. Ollie Gordon II will get the first crack to be RB1 with Jaylen Wright inactive against Kansas City . If you have Achane on your roster, your top waiver priority this week should be Gordon.