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Week 3 NFL odds, picks, predictions: Our best bets for the weekend's games

Our NFL handicappers give out their favorite bets for Week 3 games.

Yahoo Sports · September 25, 2026

Week 3 NFL odds, picks, predictions: Our best bets for the weekend's games

Our NFL handicapping team of Matt Jacob, Jeremy Pond and Matt Russell combine to give their best bets for Week 3 of the NFL season.

Jacob : Through eight quarters — all played on their home turf — the Chargers' offense has produced four touchdowns. Against two teams ( Arizona and Las Vegas ) that each finished 3-14 a year ago while ranking 28th (Cardinals) and 25th ( Raiders ) in scoring defense.

Bills quarterback Josh Allen ? He accounted for five touchdowns (three passing, two rushing) last week ! This after tallying four scores in Week 1 at Houston . In fact, in their 41-31 Week 2 win over Detroit , the Bills scored nearly as many first-half points (27) as the Chargers have scored in two games (28).

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