We make 3 predictions for the 49ers Week 3 game against the Cardinals
Yahoo Sports · September 25, 2026

San Francisco has been on a roll to start the season, securing blowout wins over the Los Angeles Rams (27-7) and the Miami Dolphins (35-13) behind their offensive engine. They haven't really been threatened in either game, dominating the second halves to get an early jump in the division race.
With how good the NFC West is, every division win counts, placing an extra emphasis on this game. The Cardinals are coming off a 31-7 loss to the Drew Lock-led Seattle Seahawks after they upset the Los Angeles Chargers 26-14 in Week 1.
It's a game the 49ers are expected to win by more than a touchdown . Those odds have remained consistent throughout the week on FanDuel Sportsbook .
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