NFL betting, odds, lines: Betting trends to know for Week 2's biggest games

On one hand, the Bengals , Bears and Giants — all notoriously slow starters in recent years — won and covered in Week 1.

Also, Houston 's nine-game overall and seven-game home winning streaks ended against the Bills. The Rams lost for just the ninth time in their past 30 regular-season games. And Tampa Bay dropped its first season opener since 2020 (falling in Cincinnati ).

Then again, Jacksonville (9-0 SU and ATS regular-season run), Seattle (11 straight victories, including the playoffs) and Minnesota (six-game heater) kept rolling, the Colts (eight straight losses), Packers (six straight losses) and Buccaneers (10 straight ATS defeats) kept failing, and the NFC South kept being, well, the NFC South (0-4 SU, 1-3 ATS).