49ers vs. Dolphins prediction: A vintage Christian McCaffrey performance

Now, in Week 2, they're seen as easily the biggest favorite on the slate as they take on the Miami Dolphins . San Francisco enters the weekend as 13.5-point favorites after starting the week as a 10.5-point favorite.

In the debut of new head coach Jeff Hafley and quarterback Malik Willis , the Dolphins lost 27-13 to the Las Vegas Raiders last weekend as they couldn't get much going offensively, with De'Von Achane rushing for just 36 yards.

The 49ers will be returning from Australia and won't get the coveted extra day of rest that the Rams are getting by playing Monday night. But there's a significant level of confidence in San Francisco heading into Sunday.